The effect of surface charge on nonspecific uptake and cytotoxicity of CdSe/ZnS core/shell quantum dots

• Vladimir V. Breus,
• Anna Pietuch,
• Marco Tarantola,
• Thomas Basché and
• Andreas Janshoff

Beilstein J. Nanotechnol. 2015, 6, 281–292, doi:10.3762/bjnano.6.26

• -particle tracking), was shown to compromise the integrity of the cytoskeletal and plasma membrane dynamics, as evidenced by electric cell–substrate impedance sensing. Keywords: biocompatibility; CdSe/ZnS; cytotoxicity; ECIS; quantum dots; single-particle tracking; Introduction Quantum dots (QDs) are

• quantify the cytotoxic effects of QDs on the viability of MDCKII cells in combination with single-particle tracking employing a wide-field fluorescence microscope [21]. The impact of QDs with different surface charges is characterized at the initial stages after exposure to cells, the stage at which

• ][27]. Furthermore, we combined ECIS with single-particle tracking, which was previously used to follow the intracellular pathway of Tat peptide-conjugated QDs in living cells [28], transport of QD-labelled monoclonal anti-HER2 antibody in mice [29], specific recognition of avidin-CD14 receptor by